NBA: Victor Wembanyama scores 50 points in San Antonio victory
Elsewhere, Giannis Antetokounmpo scored an NBA season-high 59 points and the Milwaukee Bucks defeated the Detroit Pistons 127-120 in overtime.
It was the ninth time the two-time MVP has scored 50 or more points and the second-best total of his career, after scoring 64 points against the Indiana Pacers last season.
The Cleveland Cavaliers defeated the Philadelphia 76ers 114-106, continuing their unbeaten start to the season and winning 13 consecutive games.
That success makes them the sixth team to start the year with a 13-0 record and the first since the 2015-16 Golden State Warriors.
Darius Garland scored a Cavaliers-high 25 points, and Donovan Mitchell had 23 points, 9 assists and 13 rebounds.
In Los Angeles, LeBron James recorded his third consecutive triple-double and the Lakers defeated the Memphis Grizzlies 128-123 to maintain their undefeated record at home.
James scored 35 points, 14 assists and 12 rebounds, and Anthony Davis scored 21 points and 14 rebounds.