Wales v Australia: Tomos Williams out as Warren Gatland makes four changes
Morgan will make his first start for the national team since October 2023 when Wales lost to Argentina in the World Cup quarter-finals in Marseille.
The flanker missed the 2024 Six Nations with a knee problem and the summer tour with a hamstring injury.
Morgan, 24, was left on the bench in the defeat to Fiji but impressed when he came on in the second half.
Cardiff City’s back-row Botham also performed well in the final stages of last weekend, replacing Plumtree, who withdrew from the 23-man squad, while Reiffel sat on the bench.
Cardiff City winger Grady has been ruled out of the autumn series after picking up a first-half injury against Fiji, with Rodgers preferred over Leo Dyer and Josh Hathaway.
Gatland opted for a more traditional balance of five forwards and three at the back on the bench this time, after a previous tactic of six forwards and two at the back backfired against Fiji.
After Grady was injured, Gatland admitted that he had fielded the wrong substitute, with Reds flying back Sam Costelow out of position instead of Cardiff City point guard Bevan, who was assigned Cover the wings.
Scarlets center Eddie James has been named as a substitute against Australia.